Consortium

The IOM is a major independent centre of scientific excellence in the fields of occupational and environmental health, hygiene and safety and has established a leading presence on chemical- and nanotechnology-risk issues through an international reputation in assessing the risk of small particles and fibres. The institute has expertise in hazard, exposure and risk assessment for workplace hazards, including nanomaterials and nanotechnology in support of regulation and industrial innovation.

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Aarhus University (AU) was founded in 1928. It has 42,500 students and 11.500 employees (2016). Aarhus Faculty of Science and Technology cover the entire research spectrum from basic, applied, strategic and research based advice to the authorities. In 2016 the university was within top 100 at practically all international recognised rankings of larger Universities.

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The European Research Services GmbH is a public-private-partnership that supports researchers in planning and managing EU-projects. ERS provides technical and administrative support, adapting project-management to the size and complexity of each specific project. ERS helps to implement risk assessment, internal monitoring and common standard procedures, safeguarding outcomes within time, budget, and EU guidelines.

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Environmental Assessments (ENAS) is an SME established in Germany in 2001 with a focus on research and contract work on environmental impact assessment of chemical pollutants from metal, mining, waste disposal as well as chemical industries as main business of the company. ENAS has a long experience in planning, coordination and implementation of projects assessing the environmental risk of chemicals and compliance to regulatory requirements.

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The National Research Council (CNR) is the largest public research institution in Italy, divided in 113 Institutes spread all over Italy and employing about 8000 researchers. This network of Institutes aims at promoting a wide diffusion of research competences throughout the national territory and at facilitating contacts and cooperation with local firms and organizations. ISTEC is one of the Institutes of CNR, located in Faenza, in the north-east of Italy, its research is interdisciplinary and specifically addressed to the global study of advanced ceramic materials and in particular of bioceramics.

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The Spanish National Research Council (CSIC) is the largest public institution dedicated to research in Spain and the third largest in Europe. It has a staff of ca. 11,000 employees, among these about 3,700 are permanent researchers. The CSIC has 123 institutes/Centers and produces 20% of the national scientific output. Within the 7th Framework Programme, CSIC has signed 723 actions (including 97 coordinated by CSIC and 47 ERC projects).

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The University of Manchester was formed in 2004 by the amalgamation of the Victoria University of Manchester and the University of Manchester Institute of Science and Technology. In 2004 graphene was discovered and characterizd in this University by Professors Sir Andre Geim and Sir Konstantin Novoselov.

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The University Hospital of Muenster (UKM) is part of Westfaelische Wilhelms-Universitaet (WWU) and one of the largest ultimate care and research hospital complexes in Germany. The top ranking fundamental research is supported by more than 45 M Euro third party funds and has contributed largely to the prominent international reputation of the University hospital of Muenster.

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Karolinska Institutet (KI) in Stockholm is the largest center for medical education and research in Sweden, and the Nobel Assembly at KI is entrusted with awarding the Nobel Prize in Physiology or Medicine each year. KI is one of the largest beneficiaries in EU framework programmes with almost 200 participations in FP6 and over 300 in FP7.

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The University of Torino (UNITO) is one of the largest Italian Universities, ranked 76 among the top 100 institutions in “Medicine” field by ARWU and in the second position both in the chemical sciences and in the medical sciences areas by the University National Evaluation system (VQR 2011-2014). UNITO is involved in roughly 450 formal international cooperation agreements and joint educational programs at undergraduate and doctoral level worldwide. UNITO has a long record of participation in the EU strategic research agenda, with 115 FP7 funded research projects, 4 ERC grants as host institution and 4 Research Infrastructure projects. Under H2020, 46 projects have been funded so far (2014-2016).

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Empa, the Swiss Federal Laboratories for Material Science and Technology, is a research institution within the ETH domain and plays an important role in education, science and innovation in Switzerland. It specializes in applications, focused research and development, and provides high-level services in the field of sustainable materials science and technology. Its core tasks are innovative collaboration with industry and public institutions, ensuring the safety of people and the environment, knowledge propagation and university-level teaching.

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The University of Rome Tor Vergata (URTV) is organized into 19 Departments, divided in 6 Disciplinary Areas (Economics; Law; Engineering; Arts; Medicine; Mathematics, Physics and Natural Sciences), among which The School of Medicine is the widest in terms of personnel and facilities. The School of Medicine is associated to the Tor Vergata University Hospital. URTV has been partner in 68 active projects of the EU 7th Framework Programme for Research and Technological Development; among them 13 are in the framework of the Ideas programme of the European Research Council. URTV is also involved in other 30 international research programmes.

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HWU is a research-led university specialising in science and engineering, business and management, languages and design. Staff working on this project belong to the Nano Safety Research Group (NSRG; http://nano.hw.ac.uk/) hosted within the Institutes of Life and Earth Sciences and of Biological Chemistry, Biophysics and Bioengineering which are multidisciplinary research centres that apply advances in the life and physical sciences and engineering to further biological understanding and knowledge. The NSRG specialises in the assessment of nanomaterial toxicity to human health and the environment.

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The Unit of Functional and Adaptive Biology (BFA, UMR CNRS 8251) is part of the Department of Life Sciences in the pluridisciplinary University Paris Diderot (26 000 students and 130 laboratories). BFA is composed of 7 research teams involved in the development of an innovative functional biology research centre to better understand the biological mechanisms underlying human adaptation to environmental and/or internal (endocrine, metabolic or genic) perturbations.

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TCD and its affiliated St. James’s Hospital is one of Europe’s leading universities, ranked 160th in the World according to the Times Higher Education Supplement (THES) University league tables in 2015, 40th in the World in the Times Higher Education Top 100 Most International Universities 2015, and the first University in Ireland.

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Edinburgh Napier University is one of the largest higher education institutions in Scotland located in Scotland's capital city with nearly 18,000 students including almost 4,000 international students from over 100 countries. Edinburgh Napier University’s Centre for Nano Safety, has long been recognised for its contributions to the assessment of nanomaterial interactions with biological systems, located in a £60 million purpose built campus with state of the art research facilities.

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The Toxicology department of Wageningen University and has a long track record in toxicological research and training. The group consists of a unit on food-toxicology, headed by prof. Rietjens, and a group on advanced in vitro models for the gasto-intestinal tract headed by dr. Bouwmeester. The research at WU-TOX is based on mechanistic driven research in toxicology. The research infrastructure at WU is state-of-the-art, and there is close cooperation with other national and international leading research groups. Research at WU-TOX, although fundamental in nature, has strong connections and links with industry and regulatory authorities.

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The Spanish National Institute for Agricultural and Food Research and Tecnology (INIA) is an autonomous Public Research Organization (OPI) belonging to the Ministry of Economy, Industry and Competitiveness. INIA carries out R&D&i activities through its Deputy Directorate General for Research and Technology (SGIT). SGIT personnel in 2016 included 146 researchers and 115 technologists, 160 technicians, and 266 hired personnel and grants. A total of 207 projects were carried out (from them 30 were funded by EU and 6 by other international programmes).

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The University of Aveiro (UA) is one of Portugal's 14 public universities. Founded in 1973, UA has grown into a successful, dynamic and competitive institution. The UA is integrated in the community and region, presenting a strong research dimension and offering a wide range of educational programmes, from post-secondary vocational to doctoral programmes. Committed from the start to innovation, quality and the attainment of national and international recognition in the pillars of Education, Research and Cooperation with society, the UA has built a profile based on sciences and technology and on pioneering areas. DeBio-CESAM (Department of Biology-Centre for Environmental and Marine Studies) is one of the R&D Units of the University of Aveiro Research Institute that currently integrates more than 300 researchers, from five Departments (Environment, Biology, Physics, Geosciences and Chemistry). During the last five years, CESAM published more than 2000 papers in JCR journals.

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Fraunhofer Society (FhG): The research organization FhG undertakes applied research that drives economic development and serves the wider benefit of society. IME: The institute's activities cover two main areas: Molecular Biology and Applied Ecology. The project will be handled in the division Applied Ecology. The overall aim of this division is to determine and assess the risk posed by synthetic chemicals and natural substances, and to develop appropriate strategies for the protection of humans and environment.. Comprehensive simulation experiments in laboratory wastewater treatment plants, in model dumping site and in soil (laboratory and field) are performed. To study the fate specific devices (e.g. single particle analyses, FFF) are established. Furthermore, first experiments regarding the effect of (nano-) pharmaceuticals in soil are performed.

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National Technical University of Athens (NTUA) is the oldest and most prestigious educational institution of Greece in the field of technology, and has contributed unceasingly to the country's scientific, technical and economic development since its foundation in 1836. NTUA has extensive experience in synthesis, characterisation and processing of nanomaterials as well as of nanostructured materials that can be used in the biomedical sector. Additionally, NTUA has the ability to evaluate the health and safety footprint of each process through life cycle analysis and Safe by Design approaches.

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The University Ca' Foscari of Venice (UNIVE) has an internationally outstanding reputation of academic excellence in both research and teaching. Founded in 1868 as the first Italian high school devoted to commerce and economics, it has grown and developed new relevant subject areas and nowadays is composed of 8 Departments. The Department of Environmental Sciences, Informatics and Statistics supports research activities on integrated approaches and tools for the assessment and management of impacts and risks posed by environmental stressors on human health and ecosystems, as well as by emerging technologies like nanotechnologies. A main field of expertise consists in the development of frameworks and methodologies supporting decision making on different environmental problems (e.g. contaminated sites, nanotechnologies). UNIVE has been the coordinator of the recently completed large-scale FP7 project SUN with the task to develop a decision support system for the risk assessment and management of nanomaterials.

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Founded in 1990, INERIS is a public research agency, with industrial and commercial purposes, under the supervision of the French Ministry of Ecology, Sustainable Development and Planning. The mission of ‘INERIS’ is to assess and prevent accidental and chronic risks to people and the environment generated by industrial activities, chemical substances and underground works : characterization and understanding of the phenomena that govern the risks affecting safety or property of people, health and environment as a result of economic activities; Improvement of the evaluation of such risks in order to enable decision makers in the public and private sectors to adopt the most appropriate measures to improve environmental safety.

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Leeds University (LEEDS) brings substantial research leadership and management experience to NANOCANCER. It has >32,000 students and 3,000 researchers, in 9 faculties. It is a member of the Russell Group ‘Ivy League’ universities and is the UK University of the year (2017). Its annual research income in 2016 was €154 million. LEED’s Faculty of Medicine and Health is world-leading in research for oncology, regenerative medicine, musculoskeletal and cardiovascular diseases. It is a leader in translational R&I in replacement joints. It is home to the UK’s National Institute for Health Research (NIHR) Clinical Research Network Coordinating Centre. It is a centre of excellence for clinical trials. Its university hospital is Europe’s largest teaching hospital.

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Warrant Group S.r.l. is a privately held consultancy services company that provides full-spectrum consulting in business finance. Warrant Group has been active since 1995, growing over the years to become a leader in its sector today. WG Business Units work in synergy with its Innovation Lab to give their clients the best support tools for the success of their business initiatives and to assist them in the preparation and management of strategic projects: business projects, research projects, training and technology transfer activities, under National and International support frameworks.

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BioNanoNet Forschungsgesellschaft mbH (BNN) is a non-profit scientific network that specializes in the Key Enabling Technologies nanotechnology and biotechnology, with emphasis on (1) nanotoxicology, (2) sensortechnology, as well as (3) health, (nano-)safety and (nano-)medicine. Standardisation and regulatory aspects of nanotechnology (e.g. safety data sheets, exposure scenarios, REACH context, etc.) are key topics in the research of BNN. Therefore, BNN continuously interacts with national and international stakeholders, as well as policy makers and regulatory and legislative authorities (e.g., in the context of NANoREG, EURO-NanoTox, standardisation committees, etc.).

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ITENE is the specialist Technological Center in R & D in packaging, logistics, transport and mobility. Its mission is to generate scientific and technological knowledge and added value to companies through the implementation of research and innovation activities. ITENE provides business solutions with an integrated view of the supply chain, from raw materials, design and development of packaging and packaging systems, optimization of the movement and distribution of goods, until the products reach the consumer and are ultimately managed as residues, all within a framework of sustainable performance. The centre has advanced facilities and a multidisciplinary team of researchers and technicians with a proven and constantly evolving.

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IRES is an independent Belgian project management firm (SME) administering all peripheral aspects of research projects, providing specialized services in the fields of innovation management, technology transfer and international research projects. The company's activities are focused on surveys and statistical analysis, applications of management, science methods and Impact assessment, supporting research organizations and private companies to evaluate and to exploit their innovations at international level; also, through its international network, IRES supports the development of innovative technologies and the optimization of products. Indicatively the company professionals have expertise in Project Risk, Ethics and Knowledge management, market trend analysis, feasibility studies, Impact assessment and Technology Transfer, Research in Materials Science, Development of tailored materials, Nanomaterials, Processing and Upscaling, Design and setup of prototypes, demonstrators, Ethics and integrity in research, Exploitation and Dissemination towards high technology readiness level.

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CIC biomaGUNE is a non-profit research conducting research in the field of biomaterials. The centre is composed of 11 international research teams grouped in three Units: the Biofunctional Nanomaterials Unit, the Biosurfaces Unit and the Molecular Imaging Unit, as well as a Singular Scientific and Technological Platform: the Molecular Imaging Facility. Research at CIC biomaGUNE is undertaken at the interface of biological and physical sciences.

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Nanovector is a research based company, with specific expertise in Microemulsions (μEs) and in Solid Lipid Nanoparticles (SLNs, SolinTM) obtained from warm μEs by original method: know-how collected in last 20 years on these lipid colloidal carriers is applied for development of products in therapeutics (drug delivery), in diagnostic, in nutrition and cosmetics. Surface of SolinTM has been successfully functionalized by many different physico-chemical strategies, to improve performance (cationic/anionic, PEG…) and targeting (aBody, FaB, Peptides..)

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Colorobbia Consulting S.r.l. is the services company of Gruppo Colorobbia, one of the biggest producer in the world of chemicals for ceramics. Gruppo Colorobbia is a world business company that produces and sells all over the world chemicals starting from raw material to frits (glass component of the glaze) and pigments. At present Gruppo Colorobbia has a turnover of 450.000 M€ and 1800 employees. Ce.Ri.Col, an advanced research center of the Group was strategically opened in 1999 for business diversification; its main activities are related to different field of research on nanomaterials and special glasses. The research centre is involved in more than 15 projects in different fields of application; textile, ceramic, glass, catalysis, energy, surface coating, biomedical and pharmaceutical. Ce.Ri.Col. became a department of Colorobbia Consulting in 2014. The laboratory is a reference for all the companies of the group. Two main research branches have been developed herein: 1) glass ceramics materials and their application and 2) nano-materials synthesis, scale-up and industrialization for biomedical and industrial applications.

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Finceramica is a company which develops, manufactures and markets innovative therapeutic solutions for the biomedical sector. The work carried out at Finceramica lies at the junction between the thousand-year old evolution of ceramic processes and innovation in biomaterials, biosciences and "regenerative surgery". Our research activities revolve around the human being and the specific needs of patients and surgeons. Our technology platform is a concrete answer to the daily requirements faced by orthopaedic surgery, neurosurgery and maxillofacial surgery.

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The Institute of Energy and Environmental Technology (IUTA) e.V. (100 employees, 01/2017) is a private, non-profit research institute and one of the large institutes in Germany related to research on energy and environmental issues. The institute has a long-standing history in the measurement and characterization of (nano-)particles especially in view of release, exposure and risk to engineered nanomaterials (NM) for different endpoints like worker, human health, environmental fate and behaviour.

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Established in 1784, the Royal College of Surgeons in Ireland (RCSI) (www.rcsi.ie) is a not-for-profit, private, internationally recognised institution based in Dublin with a mission to ‘educate, nurture and discover for the benefit of human health’. The RCSI is Ireland’s largest Medical School with almost 4,000 students representing over 60 nationalities. Its research mission is to improve human health through clinical and laboratory-based research informed by bedside problems, societal and global health challenges.

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The Electrospinning Company (www.electrospinning.co.uk) was founded in 2010 as a spin-off SME from the UK Science and Technology Facilities Council (STFC) to bring the benefits of the electrospinning technique into healthcare. TECL‘s primary business is the design, development and manufacture of electrospun biomaterials for use in implantable medical devices, which it offers as a contract or collaborative service.

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The French Alternative Energies and Atomic Energy Commission is a public body established in October 1945. As leader in research, development and innovation, the CEA is active in four main areas: low-carbon energies, defence and security, information technologies and health technologies. In each of these fields, the CEA maintains a cross-disciplinary culture of engineers and researchers, building on the synergies between fundamental and technological research.

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JOANNEUM RESEARCH (JR) is a leading international research organization located in Graz (Austria) that develops solutions and technologies for businesses and industry covering a wide range of sectors. JR has a focus on applied research and technology development and promotes technology transfer to industry. HEALTH -‐‐ Institute of Biomedicine and Health Sciences provides a link between basic medical research and industrial applications. HEALTH develops comprehensive, interdisciplinary solutions to problems encountered in the fields of medicine, pharmacy, medical technology and health care research.

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GreenDecision (GD) is a spin-off company of University Ca’ Foscari of Venice (UNIVE). Its mission is to transfer to European consortia and the private sector the knowledge and experience generated at UNIVE for over a decade of research on strategies and tools for risk assessment and management of chemicals and new technologies (e.g. nanotechnologies).

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Tokyo University of Science is one of the oldest universities in Japan with faculties of science, technology, economy and pharmaceutical sciences. Department of Occupational and Environmental Health is one of the leading laboratories in the field of toxicology in Japan. The university has advanced facilities of diesel inhalation system, molecular biology, cell biology as well as pathology. These profiles matchs the tasks in the proposal, namely “Development and validation of new test methods for neurotoxicity and cardiovascular toxicity”.

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The Hong Kong University of Science and Technology (HKUST) was established in 1991 as the first research university in Hong Kong. HKUST is ranked 1st Asian Top 200 Young Universities in 2017 and No. 2 in the World, 13th in Global Employability University Ranking 2016 and No. 1 in Greater China, 20th World’s Top 800 Universities (2015/2016) and No. 1 in Hong Kong. HKUST host the Nano and Advanced Materials Institute (NAMI) that function as a research institute as well as funding agency for research related to nanomaterials with an annual funding of 15 M Euro.

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Zhejiang University (ZJU) is a key comprehensive university whose fields of study cover eleven branches of learning, namely philosophy, literature, history, education, science, economics, law, management, engineering, agriculture and medicine. The total number of full time students has reached over 42,117 including more than 22,557 undergraduates, over 13,413 postgraduates working for master's degrees and over 7,398 Ph.D candidates. The university has 7 affiliated hospitals, providing medical services of various kinds for people from all over Zhejiang province.

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