Activities

BIORIMA is planned for a duration of four years. The workplan is summarized in the WP chart (see Figure). To achieve the ambitious goal and the expected TRL 5/6 for the tools and methods, an iterative approach between activities of WP 1-3 and WP6, as well as between WP4 and WP5 is expected. The selection of the NBM will be based on representative classes of biomaterials of ATMP and MD relevance. This will include compiling a library of referential type materials, including synthetized/ functionalized materials – e.g. metal/metal oxides, ceramics, organics and hybrids- produced by industrial and/or research project partners and made available to the consortium for their characterisation (See Table 1). These NBM will be characterised, tested embedded in a risk assessment-management procedures. The implementation will be compliant with current European and North American regulations, and disseminated globally.

The BIORIMA workplan is built around the life-cycle of a typical NBM. In order to achieve comprehensive coverage of each of the central themes of NBM safety research, BIORIMA is arranged into the four themes: Materials, Exposure, Hazard and Risk. Figure 3 illustrates the Life cycle of NBM with potential exposure, hazard and risk. It also illustrates the four major areas relevant to BIORIMA: Materials, Exposure, Hazard and Risk.

From left to right, The BIORIMA workplan with the respective WP; From right to left, at each stage of the NBM life-cycle, risks have to be evaluated, using the BIORIMA methods/tools and measures taken to mitigate them